Clinical significance of vascular endothelial growth factors (VEGF)-C and -D in resected non-small cell lung cancer.
作者： Yoon Ho Ko , Chan-Kwon Jung , Myung-Ah Lee , Jae Ho Byun , Jin Hyoung Kang
DOI: 10.4143/CRT.2008.40.3.133
关键词:
摘要: Purpose Lymphatic spread of tumor is an important prognostic factor for patients with non-small cell lung carcinoma (NSCLC). Vascular endothelial growth factor-C (VEGF-C) and VEGF-D play roles in lymphangiogenesis via the VEGF receptor 3 (VEGFR-3). We sought to determine whether VEGF-C, VEGFR-3 are involved clinical outcomes resected NSCLC. Materials methods Using immunohistochemical staining, we investigated protein expressions tissue array specimens from who underwent resection The immunoreactivity p53 was also examined. clinicopathological implications these molecules were statistically analyzed. Results Analysis a total 118 showed that their co-expression significantly associated more advanced regional lymph node metastasis (p=0.019, p=0.044 p=0.026, respectively, N2 versus N0 N1). A expression had strong correlation peritumoral lymphatic invasion (p=0.047). On multivariate analysis survival recurrence, pathologic only independent factor, but none any statistical recurrence survival. Conclusions present study revealed high VEGF-C strongly
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