Prognostic significance of epidermal growth factor receptor and vascular endothelial growth factor receptor in colorectal adenocarcinoma

作者: JUNG YEON KIM , BYUNG-NOE BAE , JI EUN KWON , HYUN-JUNG KIM , KYEONGMEE PARK

DOI: 10.1111/J.1600-0463.2011.02752.X

关键词:

摘要: The purpose of this study was to evaluate the association between expression growth factors and clinicopathological variables colorectal adenocarcinoma. Immunohistochemistry fluorescence in situ hybridization (FISH) were used amplification epidermal factor receptor (EGFR), vascular endothelial (VEGF), VEGF-D, VEGF (VEGFR)-2, VEGFR-3, transforming (TGF)-β1, insulin-like factor-1 (IGF-1R) a tissue microarray 292 adenocarcinomas. EGFR, VEGF, VEGFR-2 VEGFR-3 detected 5.1%, 10.0%, 6.8%, 5.2%, 57.2%. EGFR associated with angioinvasion (p < 0.05) lymph node metastasis 0.005). higher rectum than colon 0.05). correlated VEGF-D 0.005) expression, while showed no significant or VEGFR-3. present 10.6% not protein expression. levels related poor patient survival. Stage, perineural invasion, independent prognostic based on Cox analysis. are markers prognosis patients surgically resected adenocarcinoma, whereas has minor influence.

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