The C–F bond as a conformational tool in organic and biological chemistry

摘要: Organofluorine compounds are widely used in many different applications, ranging from pharmaceuticals and agrochemicals to advanced materials polymers. It has been recognised for years that fluorine substitution can confer useful molecular properties such as enhanced stability hydrophobicity. Another impact of is influence the conformations organic molecules. The stereoselective introduction atoms therefore be exploited a conformational tool synthesis shape-controlled functional This review will begin by describing some general aspects C–F bond various effects associated with bonds (i.e. dipole–dipole interactions, charge–dipole interactions hyperconjugation). Examples molecules exploit these then presented, drawing diverse range including pharmaceuticals, organocatalysts, liquid crystals peptides.