The effects of ACE inhibition on serum angiotensin II concentration following cardiac transplantation.
作者： J.E. Fildes , A.H. Walker , B. Keevil , I.V. Hutchinson , C.T. Leonard
DOI: 10.1016/J.TRANSPROCEED.2005.10.099
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摘要: Abstract Aims ANGII mediates vascular neointimal formation through smooth muscle cell stimulation and enhanced production of growth factors leading to increased arterial medial layer thickness, which is a characteristic transplant arteriosclerosis. ACE inhibition known be benefit patients with cardiovascular risk factors. We aimed determine the effect inhibitor therapy on enzymatic activity serum levels following cardiac transplantation. Methods A total 43 samples from eight recipients were used for analysis. Samples taken monthly date initial 6 months. was measured using sandwich ELISA. spectrophotometric kinetic Results There significant reduction in among individuals treated (18.0 ± 16.6 vs 31.8 23.4, P = .008). found significantly higher receiving compared those not (2.4 2.1 8.0 7.4, .002). also positive correlation between level (coefficient 0.332, .03). Conclusions Our results suggest an effective independent pathway conversion. Chymase can convert ANGI affinity than ACE. Also, chymase stored mast cells, infiltrate myocardium This data indicate that pharmacological may possible therapeutic strategy
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