Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase.
作者： Jürg A Zarn , Beat J Brüschweiler , Josef R Schlatter
DOI: 10.1289/EHP.5785
关键词:
摘要: … inhibitors of fungal sterol 14α-demethylase are inhibitors also of mammalian sterol 14α-demethylase … , data on comparative potencies of azole fungicides to fungal and human enzymes …
questia.com参考文章(81)
Keith A. Fowler, Kiran Gill, Nameer Kirma, Dirck L. Dillehay, Rajeshwar Rao Tekmal, Overexpression of aromatase leads to development of testicular Leydig cell tumors: An in vivo model for hormone-mediated testicular cancer American Journal of Pathology. ,vol. 156, pp. 347- 353 ,(2000) , 10.1016/S0002-9440(10)64736-0
Orly Lacham‐Kaplan, Kirsten M. Robertson, Evan R. Simpson, Margaret E.E. Jones, Characterization of the fertility of male aromatase knockout mice Journal of Andrology. ,vol. 22, pp. 825- 830 ,(2001) , 10.1002/J.1939-4640.2001.TB02587.X
Haitao Ji, Wannian Zhang, Youjun Zhou, Min Zhang, Jie Zhu, Yunlong Song, Jiaguo Lü, Jü Zhu, A Three-Dimensional Model of Lanosterol 14α-Demethylase of Candida albicans and Its Interaction with Azole Antifungals Journal of Medicinal Chemistry. ,vol. 43, pp. 2493- 2505 ,(2000) , 10.1021/JM990589G
J.L. Cavilla, C.R. Kennedy, M. Baltsen, L.D. Klentzeris, A.G. Byskov, G.M. Hartshorne, The effects of meiosis activating sterol on in-vitro maturation and fertilization of human oocytes from stimulated and unstimulated ovaries Human Reproduction. ,vol. 16, pp. 547- 555 ,(2001) , 10.1093/HUMREP/16.3.547
Gerald P. Bodey, Azole Antifungal Agents Clinical Infectious Diseases. ,vol. 14, ,(1992) , 10.1093/CLINIDS/14.SUPPLEMENT_1.S161
A.M Vinggaard, C Hnida, V Breinholt, J.C Larsen, Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro Toxicology in Vitro. ,vol. 14, pp. 227- 234 ,(2000) , 10.1016/S0887-2333(00)00018-7
Kathryn Lee, Valentine M. Macaulay, Joanne E. Nicholls, Simone Detre, Alan Ashworth, Mitchell Dowsett, An in vivo model of intratumoural aromatase using aromatase‐transfected MCF7 human breast cancer cells International Journal of Cancer. ,vol. 62, pp. 297- 302 ,(1995) , 10.1002/IJC.2910620311
M MIDDLETON, Ovulation in rats is delayed by a substituted triazole. Toxicology and Applied Pharmacology. ,vol. 83, pp. 230- 239 ,(1986) , 10.1016/0041-008X(86)90300-5
S. Sinha, J. Kaseta, S.J. Santner, L.M. Demers, W.J. Bremmer, R.J. Santen, Effect of CGS 20267 on ovarian aromatase and gonadotropin levels in the rat Breast Cancer Research and Treatment. ,vol. 48, pp. 45- 51 ,(1998) , 10.1023/A:1005937900788
Robin Murray, Role of anti-aromatase agents in postmenopausal advanced breast cancer. Cancer Chemotherapy and Pharmacology. ,vol. 48, pp. 259- 265 ,(2001) , 10.1007/S002800100345