Virion-Independent Transfer of Replication-Competent Hepatitis C Virus RNA between Permissive Cells
作者： Andrea Longatti , Bryan Boyd , Francis V. Chisari
DOI: 10.1128/JVI.02721-14
关键词:
摘要: In this study, we show that replication-competent subgenomic hepatitis C virus (HCV) RNA can be transferred to permissive Huh7 cells, leading the establishment of viral replication. Further, these events are mediated by exosomes rather than infectious particles. If similar occur in vivo, could represent a novel, albeit inefficient, mechanism spread and immune escape.
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