Subsequent mortality experience in five-year survivors of childhood, adolescent and young adult cancer in Scotland: a population based, retrospective cohort study.

摘要: Abstract Aim To assess the risk of death in patients who survive at least 5 years after diagnosis childhood, adolescent or young adult cancer. Patients and Methods This was a population-based retrospective cohort study using linked national cancer registry mortality records Scotland. The population consisted 5229 individuals were diagnosed with before age 25 years between 1981 2003, survived date their primary Indirect standardisation used to calculate ratios standardised for sex absolute excess risks (AERs) compared general Scottish population. Results During 58,358 person-years follow-up, there 359 deaths among survivors. overall SMR 6.1 (95% confidence interval (CI) 5.5–6.7) AER 51 (45–58) per 10,000 person-years. Largely because age- sex-related differences background mortality, SMRs higher 0–14 years (SMR 11.0, 95% CI 9.3–12.9) than 15–24 years (4.7, 4.1–5.3), females (9.2, 7.8–10.8) males (4.8, 4.2–5.5). AERs varied substantially by underlying cause death. In general, little altered an area-based indicator socio-economic deprivation. Adjusted sex, significantly lower five-year survivors during 1998–2003 those 1981–1985 (Relative hazard ratio, 0.54, 0.36–0.81). Conclusion Long-term childhood adulthood remain population, although is low has decreased over time.