The effect of therapy with olmesartan or telmisartan in patients with arterial hypertension combined with obesity.

作者: Olesia M. Bochar , Helena Y. Sklyarova , Andrij F. Faynyk , Volodymyr T. Bochar , Yurij B. Kuzminov

DOI: 10.36740/WLEK202002122

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摘要: OBJECTIVE The aim: To evaluate the hemodynamic and echocardiographic parameters, level of adiponectin IL-6 in such patients under influence therapy with sartans (telmisartan or olmesartan) atorvastatin 12 weeks later. PATIENTS AND METHODS Materials methods: Fifty arterial hypertension II stage 2 level, who underwent elective in-patient treatment were examined. During next weeks, they took olmesartan (1st group) telmisartan (2nd combination atorvastatin. RESULTS Results: combined use for had a resulted significant decrease systolic diastolic blood pressure, heart rate myocardial mass. After atorvastatin, content increased by 41.6% (p <0.05). In group receiving telmisartan, an increase was noted 80.0% shown significantly higher levels, namely 59.4% after <0.01). has decreased, both administration (2.7 times) (2.6 (p<0.01). CONCLUSION Conclusions: Telmisartan, comparison olmesartan, reduces size left ventricular atrium myocardium, decreased mass index. Telmisartan improves cardio-metabolic profile obese hypertensive concentrations levels.

参考文章(8)
Małgorzata Kubik, Jerzy Chudek, Marcin Adamczak, Andrzej Wiecek, Telmisartan improves cardiometabolic profile in obese patients with arterial hypertension. Kidney & Blood Pressure Research. ,vol. 35, pp. 281- 289 ,(2012) , 10.1159/000334951
Ilnaz Rahimmanesh, Bahman Rashidi, Marzieh Shahrezaei, High blood pressure and endothelial dysfunction: effects of high blood pressure medication on endothelial dysfunction and new treatments Journal of Research in Medical Sciences. ,vol. 17, ,(2012)
Christos V. Rizos, Moses S. Elisaf, Telmisartan: a multifaceted antihypertension drug. Current Medical Research and Opinion. ,vol. 32, pp. 1397- 1398 ,(2016) , 10.1080/03007995.2016.1176015
Yuri Nurdiantami, Kumi Watanabe, Emiko Tanaka, Julianty Pradono, Tokie Anme, Association of general and central obesity with hypertension Clinical Nutrition. ,vol. 37, pp. 1259- 1263 ,(2017) , 10.1016/J.CLNU.2017.05.012
Abdulrahman A. Al-Majed, Ahmed H.H. Bakheit, Hatem A. Abdel Aziz, Abdulelah A.M. Al-Jallal, Olmesartan Profiles of Drug Substances, Excipients and Related Methodology. ,vol. 42, pp. 241- 286 ,(2017) , 10.1016/BS.PODRM.2017.02.005
Xuhua Shen, Hongwei Li, Weiping Li, Xing Wu, Zhijun Sun, Xiaosong Ding, None, Telmisartan ameliorates adipoR1 and adipoR2 expression via PPAR-γ activation in the coronary artery and VSMCs. Biomedicine & Pharmacotherapy. ,vol. 95, pp. 129- 136 ,(2017) , 10.1016/J.BIOPHA.2017.08.041
Olesya Bochar, Eugene Sklyarov, Volodymyr Bochar, None, Leptin and interleukin-6 level in patients with hypertension and obesity combined with non-alcoholic steatohepatitis during treatment with sartans and statins Current Issues in Pharmacy and Medical Sciences. ,vol. 30, pp. 57- 60 ,(2017) , 10.1515/CIPMS-2017-0011
Shu Po Lin, Yong Tang Shi, Qing Min Wei, Chun Gui Zheng, Xiao Peng Tian, Effects of telmisartan on serum adiponectin and left ventricular remodeling in patients with essential hypertension Biomedical Research-tokyo. ,vol. 29, pp. 1455- 1458 ,(2018) , 10.4066/BIOMEDICALRESEARCH.29-17-3573