INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors.

摘要: Insulin-like peptide 5 (INSL5) is a member of the insulin superfamily, and potent agonist for RXFP4. We have shown that INSL5 expressed in enteroendocrine cells (EECs) along colorectum with gradient increase toward rectum. RXFP4 ubiquitously digestive tract. INSL5-positive EECs little immunoreactivity to chromogranin A (CgA) might be unique marker colorectal EECs. CgA-positive were distributed normally null mice, suggesting not required development Exogenous did affect proliferation human colon cancer cell lines, chemically-induced colitis mice show any significant changes inflammation or mucosal healing compared wild-type mice. In contrast, all rectal neuroendocrine tumors examined co-expressed may EECs, INSL5–RXFP4 signaling play role an autocrine/paracrine fashion epithelium tumors.