Regulation of a Transcription Factor Network Required for Differentiation and Metabolism
作者： Stephen A Duncan , M Angeles Navas , Daniel Dufort , Janet Rossant , Markus Stoffel
DOI: 10.1126/SCIENCE.281.5377.692
关键词:
摘要: Hepatocyte nuclear factors (HNFs) are a heterogeneous class of evolutionarily conserved transcription that required for cellular differentiation and metabolism. Mutations in HNF-1α HNF-4α genes impair insulin secretion cause type 2 diabetes. Regulation HNF-4/HNF-1 expression by HNF-3α HNF-3β was studied embryoid bodies which one or both alleles were inactivated. positively regulated the HNF-4α/HNF-1α their downstream targets, implicating role also necessary . In contrast, acts as negative regulator demonstrating have antagonistic transcriptional regulatory functions vivo. does not appear to act classic biochemical repressor but rather exerts its effect competing HNF-3 binding sites with more efficient activator addition, HNF-3α/HNF-3β ratio is modulated presence insulin, providing evidence HNF network may important roles mediating action insulin.
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