Evolution of the Liquid Biopsy in Metastatic Prostate Cancer
作者： Jose G. Moreno , Leonard G. Gomella
DOI: 10.1016/J.UROLOGY.2019.06.006
关键词:
摘要: We reviewed the literature for biologic, prognostic, and predictive significance of circulating prostate cancer tumor cells (CTCs), DNA in blood metastatic castration resistant patients. CTCs demonstrate robust prognostic value independent PSA predicting overall survival. The CTC androgen receptor variant 7 phenotype predicts resistance to synthesis inhibitors sensitivity taxane based chemotherapy patients who are candidates second line therapy. Research is rapidly pivoting toward analysis because approach sensitive, cost effective, it can elucidate mechanisms systemic
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