Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas.

摘要: We compared hyperplastic-like polyps that preceded microsatellite-unstable adenocarcinomas to incidental hyperplastic identify distinguishing morphologic criteria. The study group included 106 hyperplastic-like, nonadenomatous, serrated polyps, most from the ascending colon in 91 patients; control rectosigmoid patients whom adenocarcinoma did not develop. Study had an expanded crypt proliferative zone, a architectural outline became apparent basilar regions, dilation, inverted crypts, and predominance of dysmaturational crypts (crypts with minimal cell maturation). In contrast, zone confined basal region, architecture superficial rare no or crypts. Hyperplastic-like distinctive constellation features related altered decreased function resulted Dysmaturation constitutes range alterations, some which overlap incidental-type innocuous polyps. described herein provide initial guidelines this potentially important subset premalignant serrated-like