Distinctive clinical and histologic features in cutaneous melanoma with copy number gains in 8q24.

摘要: Cutaneous melanoma may be quite heterogeneous in its clinical, histologic, and molecular features. Yet, the current classification of is limited to 4 main subtypes on basis clinical histopathologic features has shown impact management including prognostication treatment. Advances our understanding driving pathways importance mitogen-activated protein kinase pathway have that specific activating mutations oncogenes correlate with characteristic histologic We evaluated 40 cases gains MYC at 8q24, we show their include aggressive course, occurrence nonchronically sun-damaged skin, amelanotic appearance, a nodular or primary dermal growth pattern by histology, frequent epidermal consumption, infrequent association precursor nevus. The v-raf murine sarcoma viral oncogene homolog B1 (BRAF) neuroblastoma RAS (NRAS) mutation status was also determined. presence these comparable frequencies previously reported from skin. However, BRAF mutant did not considered melanoma. Considering distinct possible role as theragnostic tool, it value consider 8q24 cutaneous addition future studies integrating findings into system for