A reagent based DOS strategy via Evans chiral auxiliary: highly stereoselective Michael reaction towards optically active quinolizidinones, piperidinones and pyrrolidinones
作者： Subhabrata Sen , Siva R Kamma , Rambabu Gundla , Uma Adepally , Santosh Kuncha
DOI: 10.1039/C2RA22115B
关键词:
摘要: In the present study, we have demonstrated diversity oriented synthesis of nitrogen heterocycles viz. chiral piperidinones, quinolizidinones and diaryl pyrrolidinones from Michael adducts generated via a TiCl4-catalyzed highly stereoselective reaction with nitrostyrenes an Evans auxiliary. We also reported Cu-4,4’-(isopropyl)-substituted isopropylidene-bridged 2,2’-bis-1,3’-oxazoline catalyst mediated catalytic asymmetric version this reaction. silico analysis is utilized to evaluate set compounds against shape space (PMI), polar surface area (PSA) calculations relevant drug like properties (viz. HBA, HBD, PSA, mol. wt., log P D). Finally, molecules were screened microorganisms assess their antimicrobial properties.
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