Ultrastructural Features of Invasion in Chick Embryo Liver Metastasis of Yoshida Ascites Hepatoma

摘要: Establishment of metastatic growth by Yoshida Ascites Hepatoma 7974 in the chick embryo liver has been studied with light and electron microscopy. Tumor cells lie as emboli within sinusoids for first 24 hr then begin to divide invade parenchyma 48 after inoculation. At this time, tumor are seen extend pseudopodia beneath endothelium, which many instances is disrupted advancing tumor. There a concurrent loss tight junctions epithelial organization cell islands. By 72 inoculation, well established parenchyma, intimate contact hepatic cells. The parenchymal cells, however, show no obvious ill effects host-parasite interaction.