Analysis of the polymorphisms EGFR-r521K and ERBB2-I655V in Mexican patients with gastric cancer and premalignant gastric lesions.
作者： Andrea Rebeca Bustos-Carpinteyro , Josefina Yoaly Sánchez-Lopez , Javier Torres , Juan Heriberto Torres-Jasso , María Eugenia Marín
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摘要: The proto-oncogenes epidermal growth factor receptor (EGFR) and erythroblastic leukemia viral oncogene homolog 2 (ERBB2), are involved in the development of diverse malignant tumors, including gastric cancer. We analyzed association SNPs EGFR-R521K ERBB2-I655V with cancer premalignant lesions Mexican patients. Through restriction fragment length polymorphisms, we analyze both DNA from 155 patients lesions, 121 controls, 103 people general population. frequencies did not differ significantly between any groups (chi2 p = NS); Odds ratio analysis showed that alleles EGFR-521K ERBB2-655V were related to or Our data suggest polymorphisms suitable as markers for identifying individuals a higher risk developing our
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