Laryngeal reflex apnea in neonates: effects of CO2 and the complex influence of hypoxia.
作者： L. Xia , J.C. Leiter , D. Bartlett
DOI: 10.1016/J.RESP.2013.01.004
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摘要: Abstract We have examined influence of hypocapnia, mild hypercapnia and hypoxia on the durations fictive apnea respiratory disruption elicited by injection 0.1 ml water into laryngeal lumen—the chemoreflex (LCR)—in 20 unanesthetized, decerebrate, vagotomized piglets aged 4–10 days that were paralyzed ventilated with a constant frequency tidal volume. The LCR was enhanced hypocapnia attenuated as reported others. responses to stimulation during varied complex: some animals showed abbreviated tachypnea early hypoxia, followed after 10–15 min more prolonged accompanying reduction in ventilatory activity commonly occurs sustained neonates. speculate this later hypoxic enhancement may be due accumulation adenosine brain stem.
sci-hub.se 参考文章(45)
Prem Kumar, Systemic Effects Resulting from Carotid Body Stimulation– Invited Article Advances in Experimental Medicine and Biology. ,vol. 648, pp. 223- 233 ,(2009) , 10.1007/978-90-481-2259-2_26
Brent Lanier, Mark A Richardson, Charles Cummings, Effect of hypoxia on laryngeal reflex apnea--implications for sudden infant death. Otolaryngology-Head and Neck Surgery. ,vol. 91, pp. 597- 604 ,(1983) , 10.1177/019459988309100602
John C. Lee, S. Evans Downing, Laryngeal chemosensitivity: a possible mechanism for sudden infant death. Pediatrics. ,vol. 55, pp. 640- 649 ,(1975)
Robert G. Meny, Dorothy H. Kelly, John L. Carroll, Mary Terese Carbone, Cardiorespiratory Recordings From Infants Dying Suddenly And Unexpectedly at Home Pediatrics. ,vol. 93, pp. 44- 49 ,(1994)
E. E. Lawson, Recovery from central apnea: effect of stimulus duration and end-tidal CO2 partial pressure Journal of Applied Physiology. ,vol. 53, pp. 105- 109 ,(1982) , 10.1152/JAPPL.1982.53.1.105
John M. Bissonnette, Mechanisms regulating hypoxic respiratory depression during fetal and postnatal life American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 278, ,(2000) , 10.1152/AJPREGU.2000.278.6.R1391
Luxi Xia, Donald Bartlett, J.C. Leiter, An adenosine A2A antagonist injected in the NTS reverses thermal prolongation of the LCR in decerebrate piglets Respiratory Physiology & Neurobiology. ,vol. 164, pp. 358- 365 ,(2008) , 10.1016/J.RESP.2008.08.002
Liesbeth van der Velde, Aidan K. Curran, James J. Filiano, Robert A. Darnall, Donald Bartlett, J. C. Leiter, Prolongation of the laryngeal chemoreflex after inhibition of the rostral ventral medulla in piglets: a role in SIDS? Journal of Applied Physiology. ,vol. 94, pp. 1883- 1895 ,(2003) , 10.1152/JAPPLPHYSIOL.01103.2002
Scott A. Sasse, Richard B. Berry, Tan K. Nguyen, Richard W. Light, C. Kees Mahutte, Arterial Blood Gas Changes During Breath-holding From Functional Residual Capacity Chest. ,vol. 110, pp. 958- 964 ,(1996) , 10.1378/CHEST.110.4.958
D. Zhou, Q. Huang, M-L. Fung, A. Li, R.A. Darnall, E.E. Nattie, W.M. St. John, Phrenic response to hypercapnia in the unanesthetized, decerebrate, newborn rat Respiration Physiology. ,vol. 104, pp. 11- 22 ,(1996) , 10.1016/0034-5687(95)00098-4