Vascular basis of Alzheimer's pathogenesis.
作者： J. C. TORRE
DOI: 10.1111/J.1749-6632.2002.TB04817.X
关键词:
摘要: Considerable evidence now indicates that Alzheimer's disease (AD) is primarily a vascular disorder. This conclusion supported by the following evidence: (1) epidemiologic studies linking risk factors to cerebrovascular pathology can set in motion metabolic, neurodegenerative, and cognitive changes Alzheimer brains; (2) AD dementia (VaD) share many similar factors; (3) pharmacotherapy improves insufficiency also symptoms; (4) preclinical detection of potential possible from direct or indirect regional cerebral perfusion measurements; (5) overlapping clinical symptoms VaD; (6) parallel neurodegenerative (7) hypoperfusion trigger hypometabolic, cognitive, degenerative changes; (8) arise cerebromicrovascular pathology. The collective data presented this review strongly indicate present classification incorrect should be changed Such change would accelerate development better treatment targets, patient management, diagnosis, prevention disorder focusing on root problem. In addition, theoretical capsule summary detailing how may develop chronic role critically attained threshold (CATCH) nitric oxide derived endothelial synthase triggering cataclysmic
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