[The macular pigment: short- and intermediate-term changes of macular pigment optical density following supplementation with lutein and zeaxanthin and co-antioxidants. The LUNA Study]

摘要: BACKGROUND How long do the elevated concentrations of macular pigment persist after stopping supplementation with lutein and zeaxanthin? METHODS One hundred eight (108) probands without age-related degeneration (68 female, 40 male, age 51-87 years) received a supplement containing 12 mg 1 zeaxanthin once per day (Ocuvite lutein) for 6 months. Analysis optical density (MPOD) was performed during period again 3, 6, 9 months following discontinuation supplement. A control group 28 subjects no dietary RESULTS At baseline, mean MPOD at 0.5 degrees 0.50 in supplemented group. Following supplementation, values rose, 3 highest levels MPOD0.5 (0.59 ODU) were detected (increase +0.1 ODU, (p<0.001). Six discontinuation, slight decrease appeared (to 0.54 ODU), followed by increase later 0.57 ODU). An increment not significant (0.03 p=0.15). DISCUSSION Supplementation leads to an . This effect outlasts duration intake, stopped, still compared baseline levels. longer follow-up subsequent might clarify whether over time or plateau is reached. High doses seem be necessary retina; afterwards, amount carotenoids needed maintain high seems covered daily food.