Calciphylaxis due to hyperparathyroidism.

摘要: ABSTRACT Objective To discuss when and how to workup calciphylaxis for early diagnosis delineate medical vs surgical management of the disease. Methods Review evidence-based literature on due primary, secondary, tertiary hyperparathyroidism. Results Calciphylaxis is usually associated with secondary However, can also be seen in absence chronic renal failure has been reported patients primary hyperparathyroidism a parathyroid adenoma or carcinoma. occurs levels calcium phosphate blood exceed their solubility level, leading calcium-phosphate deposits arteries that compromise vasculature. These ischemic changes result plaque-like lesions progress painful nodules. diagnosed basis physical examination, laboratory, histopathologic findings. When therapy failed setting secondary/tertiary calciphylaxis, parathyroidectomy preferred treatment. In hyperparathyroidism, recognition aggressive wound care debridement are important managing this condition. resection offending gland should strongly considered. Conclusions present, detection critical successful Although effective, diseased glands curative potentially life saving. A multidisciplinary approach involving diagnosis, management, operative debridement, best chance improving survival calciphylaxis. (Endocr Pract. 2011;17[Suppl 1]:54-56)