Repair and recombination induced by triple helix DNA
作者： Joanna Y Chin , Erica B Schleifman , Peter M Glazer
DOI: 10.2741/2388
关键词:
摘要: Triple-helix DNA structures can form endogenously at mirror repeat polypurine/polypyrimidine sequences or by introduction of triplex-forming oligonucleotides (TFOs). Recent evidence suggests that triple helices are sources genetic instability, and subject to increased rates mutagenesis recruitment repair factors. Indeed, observations using TFOs suggest provoke a variety biological processes which be harnessed modulate gene expression induce heritable changes in targeted genes. This review surveys the applications TFOs, with particular attention their recombinogenic mutagenic potential, summarizes available for mechanism triplex triplex-associated repair.
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