Oleanolic acid potentiates the antitumor activity of 5-fluorouracil in pancreatic cancer cells
作者： JIANTENG WEI , HAIZHOU LIU , MING LIU , NING WU , JIN ZHAO
DOI: 10.3892/OR.2012.1921
关键词:
摘要: The antitumor activity of oleanolic (OA) has attracted attention due to its marked effects and pharmacological safety. In the present study, combination OA 5-fluorouracil (5-FU) on Panc-28 human pancreatic cells were studied. results showed that combined use 5-FU synergistically potentiated cell death cells, pro-apoptotic also increased. Further study revealed treatment could enhance mitochondrial depolarization, lysosomal membrane permeabilization (LMP) leakage cathepin D, while release cytochrome C did not display significant changes. expression apoptosis related proteins was affected in treated with 5-FU, including activation caspases-3 Bcl-2/Bax, survivin NF-kappa B. Our provide evidence may serve as a novel strategy for cancer.
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