Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line.

摘要: Patients with glioblastoma multiforme (GBM) have poor therapeutic outcomes despite their current therapy. In an attempt to increase the efficacy of therapy for GBM, we studied arsenic trioxide (ATO), a newly introduced treatment glioma, combined silibinin, natural polyphenolic flavonoid, in GBM cell line, U87MG. The combination synergically inhibited metabolic activity, proliferation, and gelatinase A B activities; it also increased apoptosis. Additionally, decreased mRNA level cathepsin B, uPA, matrix metalloproteinase-2 9, membrane type 1-MMP, survivin, BCL2, CA9; caspase-3. Altogether, these results showed that ATO silibinin some cases improved and/or complemented anticancer effects. This study may supply insight into design new cancer therapies cells intrinsically less sensitive routine suggested highly invasive human glioma treatment.