A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions
作者： T. Sudhof , F Lottspeich , P Greengard , E Mehl , R Jahn
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摘要: Complementary DNA and genomic clones were isolated sequenced corresponding to rat human synaptophysin (p38), a major integral membrane protein of synaptic vesicles. The deduced amino acid sequences indicate an evolutionarily highly conserved that spans the four times. Both carboxyl termini face cytoplasm, with latter containing ten copies tyrosine-rich pentapeptide repeat. structure suggests may function as channel in vesicle membrane, terminus serving binding site for cellular factors.
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