Cellular mechanism of resistance of human colorectal adenocarcinoma cells against apoptosis-induction by Russell's Viper venom l-amino acid oxidase (Rusvinoxidase).
作者： Ashis K. Mukherjee , Anthony J. Saviola , Stephen P. Mackessy
DOI: 10.1016/J.BIOCHI.2018.04.017
关键词:
摘要: Abstract The present study highlights the cellular mechanism of resistance in human adenocarcinoma (Colo-205) cells against apoptosis induction by Rusvinoxidase, an l -amino acid oxidase purified from Russell's Viper venom (RVV). significantly lower cytotoxicity as well apoptotic activity Rusvinoxidase towards Colo-205 cells (compared to MCF-7 breast cancer cells) is correlated with depletion glutathione content and increased down-regulation catalase following treatment. Exposure subsequently diminished reactive oxygen species (ROS) production failed impair mitochondrial membrane potential, resulting Colo-205 cells. Further, higher expression levels caspase 8, compared 9, indicate that preferentially triggers extrinsic pathway A time-dependent ratio relative Bax Bcl-xL (pro- anti-apoptotic proteins) Colo-205 cells, our previous on MCF-7 cells, unambiguously supports a Rusvinoxidase-induced apoptosis.
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