Randomized Double-Blind Trial of Prophylactic Oral Minocycline and Topical Tazarotene for Cetuximab-Associated Acne-Like Eruption

摘要: Purpose To evaluate the ability of either oral minocycline, topical tazarotene or both, to reduce prevent cetuximab-related acneiform rash when administered starting on day 1 cetuximab therapy. Patients and Methods Metastatic colorectal cancer patients preparing initiate were randomly assigned receive daily minocycline placebo, application left right side face. Both therapies for 8 weeks. Results Forty-eight eligible (n = 24) placebo 24). Total facial lesion counts significantly lower in receiving at weeks through 4. At week 4, a proportion arm reported moderate severe itch than (20% v 50%, P .05). Facial photographs, obtained reviewed global severity. trended toward frequency ras...