Lectins for Drug Delivery within the Oral Cavity—Investigation of Lectin Binding to Oral Mucosa
作者： P. K. K. Nantwi , D. J. Cook , D. J. Rogers , J. D. Smart
DOI: 10.3109/10611869708995857
关键词:
摘要: AbstractThe aim of this study was to identify receptors present on the buccal mucosa in order select appropriate lectins that will allow retention a dosage form within oral cavity. Studies using human cells, avidin-biotin-complex/diaminobenzidine method for identifying lectin binding and microdensitometer semi-quantitative analysis stain intensity, showed wide diversity receptors. Kinetic studies cells revealed significant after 20 s, particularly from Pisum sativum Arachis hypogaea. A reduction observed exposing series solutions pre-treated with large excess secretor or non-secretor saliva. However when bound there little displacement exposure either saliva types. Further rat tissue suggested appeared bind varying degrees whole epithelial sur...
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