摘要: The high mortality and widespread impact of malaria have resulted in this disease being the strongest evolutionary selective force recent human history, genes that confer resistance to provide some best-known case studies strong positive selection modern humans. I begin by reviewing JBS Haldane's initial contribution potential genetic Further, discuss population genetics aspects many variants, including globin, G6PD deficiency, Duffy, ovalocytosis, ABO leukocyte antigen variants. Many variants conferring are ‘loss-of-function’ mutants appear be polymorphisms from last 5000–10 000 years or less. estimation coefficients case–control data make predictions about change for S, C G6PD-deficiency In addition, consider predicted joint changes when two β-globin alleles S both variable same there is a variation α-thalassemia unlinked, but epistatic As more becomes known humans, approaches can contribute investigating past predicting consequences future generations these
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