A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance
作者： Ronen Loebstein , Ilana Dvoskin , Hillel Halkin , Manuela Vecsler , Aharon Lubetsky
DOI: 10.1182/BLOOD-2006-08-038984
关键词:
摘要: CYP2C9 and VKORC1 genetic variants are associated with low intermediate warfarin dose requirements, but markers of high doses less well characterized. We analyzed the coding sequence known polymorphisms in 15 selected warfarin-resistant (dose, 80 to 185 mg/wk) 8 warfarin-sensitive patients (7 13 99 unselected controls (8 105 mg/wk). identified a Asp36Tyr polymorphism 7 resistant compared 0 sensitive ( P = .026) Carriers control group 99) required significantly higher 80.9 ± 10.1 mg/wk 42.7 7.5 noncarriers (F 9.79, .002). was more than 70 (odds ratio, 13.0; 95% confidence limit, 1.3 124.2), while 20 were (partial r2 .11; .004), CYP2C9*2 *3 .08; .01), VKORC1*2 .05; .05). All carriers also had VKORC1*1 tag–single nucleotide (tag-SNPs) indicating new haplotype. common Jewish ethnic groups Ethiopian (15%) Ashkenazi (4%) origin. suggest that is marker end dosing range.
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