The delicate dance of translation and folding

摘要: The past decade has seen rapid growth in our knowledge of how proteins are synthesized cells. This includes the basic step transfer RNAs (tRNAs) decode messenger (mRNAs) with high fidelity and speed, ribosome moves along mRNA from codon to during translation, synthesis corresponding polypeptide chain is initiated terminated at specific points on ( 1 ). Structures ribosomal particles—megadalton RNA-protein assemblies—have provided detailed molecular views active sites for decoding peptide bond formation, suggested pathways movement ligands, factors, subunits themselves. Obscured this rich cache fate protein product. How does it fold translation might folding affect itself? These questions addressed by elegant biophysical biochemical approaches reported Goldman et al. 2 ) Kim 3 pages 457 444, respectively, issue, adding a growing appreciation cotranslational 4 – 6