The Direct Binding of a p58 Killer Cell Inhibitory Receptor to Human Histocompatibility Leukocyte Antigen (HLA)-Cw4 Exhibits Peptide Selectivity
作者： Sumati Rajagopalan , Eric O. Long
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摘要: Natural killer (NK) cells in mice and humans express a number of structurally diverse receptors that inhibit target cell lysis upon recognition major histocompatibility complex (MHC) class I molecules expressed on targets. The contribution peptide to the structural features required for NK inhibition appears vary depending type receptor engaged. Thus, while there is no specificity mediated by Ly-49A mouse, human antigen (HLA)-B*2705–specific clones displayed selectivity peptides. In this report, we examine role HLA-C defined inhibitory (KIR) cl42 with established HLA-Cw4. Binding soluble KIR HLA-Cw4 transporter associated presentation (TAP)-deficient RMA-S occurred only exogenous loading. Moreover, was certain substitutions at positions 7 8 nonamer QYDDAVYKL abolished Cw4 interaction despite similar surface expression HLA-C. direct between peptideloaded correlated they were inhibited loaded appropriate
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L L Lanier, C Chang, S Lazetic, J P Houchins, J H Phillips, Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. Journal of Immunology. ,vol. 157, pp. 4741- 4745 ,(1996)
K.C. Parker, B.M. Carreno, L Sestak, U Utz, W.E. Biddison, J.E. Coligan, Peptide binding to HLA-A2 and HLA-B27 isolated from Escherichia coli. Reconstitution of HLA-A2 and HLA-B27 heavy chain/beta 2-microglobulin complexes requires specific peptides. Journal of Biological Chemistry. ,vol. 267, pp. 5451- 5459 ,(1992) , 10.1016/S0021-9258(18)42787-1
Jacqueline Samaridis, Marco Colonna, Christian Döhring, Marina Cella, Doris Scheidegger, A human killer inhibitory receptor specific for HLA-A1,2. Journal of Immunology. ,vol. 156, pp. 3098- 3101 ,(1996)
Eric O. Long, Kenneth C. Parker, Mauro S. Malnati, Marta Peruzzi, Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells. Journal of Immunology. ,vol. 157, pp. 3350- 3356 ,(1996)
M F del Guercio, S Southwood, R T Kubo, V H Engelhard, M Takiguchi, K Falk, O Rötzschke, H G Rammensee, J Sidney, E Appella, Several HLA alleles share overlapping peptide specificities. Journal of Immunology. ,vol. 154, pp. 247- 259 ,(1995)
K Franz-Bacon, L L Lanier, T McClanahan, C Chang, A D'Andrea, J H Phillips, Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. Journal of Immunology. ,vol. 155, pp. 2306- 2310 ,(1995)
Joseph H. Phillips, Chiwen Chang, Jeanine Mattson, Jenny E. Gumperz, Peter Parham, Lewis L. Lanier, CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes. Immunity. ,vol. 5, pp. 163- 172 ,(1996) , 10.1016/S1074-7613(00)80492-6
Q. R. Fan, D. N. Garboczi, C. C. Winter, N. Wagtmann, E. O. Long, D. C. Wiley, Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 7178- 7183 ,(1996) , 10.1073/PNAS.93.14.7178
M S Malnati, P Lusso, E Ciccone, A Moretta, L Moretta, E O Long, Recognition of virus-infected cells by natural killer cell clones is controlled by polymorphic target cell elements Journal of Experimental Medicine. ,vol. 178, pp. 961- 969 ,(1993) , 10.1084/JEM.178.3.961
M. Malnati, M. Peruzzi, K. Parker, W. Biddison, E. Ciccone, A. Moretta, E. Long, Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones Science. ,vol. 267, pp. 1016- 1018 ,(1995) , 10.1126/SCIENCE.7863326