Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: Pharmacotherapies in Cardiac Critical Care Anticoagulation and Thrombolysis.

摘要: Objective Thrombotic complications are increasingly being recognized as a significant cause of morbidity and mortality in pediatric congenital heart disease. The objective this article is to review the medications currently available prevent treat such complications. Data sources Online searches were conducted using PubMed. Study selection Studies selected for inclusion based on their scientific merit applicability cardiac population. extraction Pertinent information from each study or was extracted inclusion. synthesis Four classes identified potentially beneficial patient group: anticoagulants, antiplatelet agents, thrombolytic novel oral anticoagulants. class medication synthesized into follow sections: mechanism action, pharmacokinetics, dosing, monitoring, reversal, considerations use, evidence support. Conclusions Anticoagulants, agents routinely used successfully with disease prevention treatment wide range thrombotic Although anticoagulants have been approved limited number indications adults, studies safety efficacy these children pending.