The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells.

摘要: There is accumulating evidence that secondary plant metabolites such as flavonoids may have anti-cancer properties, and yet the molecular pathways lead to alterations in cancer cell behaviour remain unclear. We investigated possible actions of apigenin, a flavone present leafy vegetables like parsley, on levels CD26 carcinoma cells. multifunctional cell-surface protein through its associated dipeptidyl peptidase (DPPIV) ecto-adenosine deaminase (eADA) enzyme activities able suppress involved tumour metastasis. down-regulated various cancers including colorectal carcinoma. Apigenin substantially up-regulated HT-29 HRT-18 human Levels protein, along with DPPIV activity, capacity bind eADA, ability link cells fibronectin, were increased maximum after 24–48 h. Elevation occurred at concentrations least 10-fold less than those shown affect growth, 100-fold below could viability. Furthermore, effect was enhanced when apigenin paired chemotherapeutic agents utilized treatment advanced irinotecan, 5-fluorouracil oxaliplatin. For caused 4-fold increase potency drug. These results demonstrate can cellular multiple functions, oppose predicted decreased eADA cells, which facilitate growth