Hepatic toxicity of antitubercular agents. Role of different drugs. 199 cases

摘要: One hundred and ninety-nine cases of hepatic injury related to antituberculous treatment were analysed in order assess the role played by each drug look for predisposing factors. This is a retrospective study 169 reported literature 30 regional pharmacovigilance centre Paris Saint-Antoine. The mortality rate was dose isoniazid: it 43 percent with daily higher than 300 mg, 9 mg or less (P < 0.001). Hepatic appeared significantly earlier case rifampicin combination: 11 weeks without 2 0.01). pyrazinamide difficult determine because isoniazid always used combination. influence preexisting liver disease could not be evaluated small number (8 cases). Alcoholism did increase rate. Our results confirm dose-dependent toxicity isoniazid. Because short time elapsed before apparent onset hepatitis observed combination, close supervision patients should exerted during first treatment.