EVALUATION OF RISK FACTORS FOR ANTITUBERCULOSIS DRUGS-INDUCED HEPATOTOXICITY IN NEPALESE POPULATION

摘要: Antitubercular drugs cause derangement of hepatic functions revealed by clinical examination and abnormal liver function test. Many factors are found to predispose patients towards this adverse reaction anti-tubercular drugs, which can economical burden as well prolong duration illness. Detection these risk for hepatotoxicity play an important role in minimizing the incidence. The present study had obejectives assess age, sex, alcohol intake, nutritional status disease extent development with active tuberculosis receiving antituberculosis treatment. 50 diagnosed infection normal pretreatment were monitored clinically biochemically a prospective cohort analysis. Four (8%) developed drug-induced hepatotoxicity. drugsinduced was prevalent younger (6% vs. 2%, P> 0.05, P = 0.368, Odds Ratio [OR]; 2.75). Female gender be at higher (P> 0.219, ratio 4.2). Majority who sputum smear positive ones advanced infection. Nutritional status, assessed body mass index (BMI) serum albumin level, next predisposing factor. Risk included female poor status. Timely detection temporary withdrawal offending agent completely cure antitubercular drugs-induced