Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients.
作者： Hui Yang , Lihua Qiu , Guangjie Chen , Zi Ye , Caijun Lü
DOI: 10.1016/J.FERTNSTERT.2007.03.037
关键词:
摘要: Objective To investigate the proportional changes of CD4 + CD25 regulatory T cells in peripheral blood and decidua unexplained recurrent spontaneous abortion (URSA) normal pregnant (NP) women. Design Prospective, case–control study. Setting Large public hospital a major city China. Patient(s) Twenty-five URSA patients 34 normal, early pregnant, control Intervention(s) Measurements blood. Main Outcome Measure(s) The proportion bright cells; percentage T-cell population. Result(s) proportions both were statistically significantly lower than those Meanwhile, population was higher that women, whereas difference not significant who have URSA. Conclusion(s) Human play role tolerating conceptus antigens therefore may contribute to maintenance pregnancy. data suggest be novel target therapy.
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T Morii, N Narita, S Saito, K Nishikawa, M Ichijo, M Enomoto, Expression of activation antigens CD69, HLA-DR, interleukin-2 receptor-alpha (IL-2R alpha) and IL-2R beta on T cells of human decidua at an early stage of pregnancy. Immunology. ,vol. 75, pp. 710- 712 ,(1992)
Clare Baecher-Allan, Julia A. Brown, Gordon J. Freeman, David A. Hafler, CD4+CD25high Regulatory Cells in Human Peripheral Blood Journal of Immunology. ,vol. 167, pp. 1245- 1253 ,(2001) , 10.4049/JIMMUNOL.167.3.1245
Ole B. Christiansen, Anne-Marie Nybo Andersen, Ernesto Bosch, Salim Daya, Peter J. Delves, Thomas V. Hviid, William H. Kutteh, Susan M. Laird, Tin-Chiu Li, Katrin van der Ven, Evidence-based investigations and treatments of recurrent pregnancy loss. Fertility and Sterility. ,vol. 83, pp. 821- 839 ,(2005) , 10.1016/J.FERTNSTERT.2004.12.018
J. HEIKKINEN, M. MOTTONEN, A. ALANEN, O. LASSILA, Phenotypic characterization of regulatory T cells in the human decidua Clinical and Experimental Immunology. ,vol. 136, pp. 373- 378 ,(2004) , 10.1111/J.1365-2249.2004.02441.X
Varuna R Aluvihare, Marinos Kallikourdis, Alexander G Betz, Regulatory T cells mediate maternal tolerance to the fetus. Nature Immunology. ,vol. 5, pp. 266- 271 ,(2004) , 10.1038/NI1037
T TILBURGS, D ROELEN, B VANDERMAST, J VANSCHIP, C KLEIJBURG, G DEGROOTSWINGS, H KANHAI, F CLAAS, S SCHERJON, Differential Distribution of CD4+CD25bright and CD8+CD28− T-cells in Decidua and Maternal Blood During Human Pregnancy Placenta. ,vol. 27, pp. 47- 53 ,(2006) , 10.1016/J.PLACENTA.2005.11.008
Duojia Cao, Vivianne Malmström, Clare Baecher-Allan, David Hafler, Lars Klareskog, Christina Trollmo, Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis European Journal of Immunology. ,vol. 33, pp. 215- 223 ,(2003) , 10.1002/IMMU.200390024
G DARASSEJEZE, D KLATZMANN, F CHARLOTTE, B SALOMON, J COHEN, CD4+CD25+ regulatory/suppressor T cells prevent allogeneic fetus rejection in mice. Immunology Letters. ,vol. 102, pp. 106- 109 ,(2006) , 10.1016/J.IMLET.2005.07.002
David A. Somerset, Yong Zheng, Mark D. Kilby, David M. Sansom, Mark T. Drayson, Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology. ,vol. 112, pp. 38- 43 ,(2004) , 10.1111/J.1365-2567.2004.01869.X
C Bulletti, Reproductive failure due to spontaneous abortion and recurrent miscarriage Human Reproduction Update. ,vol. 2, pp. 118- 136 ,(1996) , 10.1093/HUMUPD/2.2.118