Chemotherapy of small cell lung cancer.

摘要: INTRODUCTION THE MANAGEMENT of patients with small cell lung cancer (SCLC) has undergone major changes during the past 20 years. Before 1970 surgery and radiotherapy were most common forms treatment, but these local methods provided only rarely effective long-term control, when used as single treatment modality. Appreciation frequency extent metastases coupled sensitivity SCLC to a variety chemotherapeutic agents have since then led present emphasis upon central role systemic chemotherapy. These resulted in 5 fold increase median survival disease-free over three years duration 10% group whole, 15 20% presenting limited disease other favourable prognostic factors [I]. Even though considerable progress been achieved, there is still no standardised for SCLC. Work being carried out many centres national international groups obtain further knowledge special biological features this entity, including search alternative treatments, hope that it will become more readily curable disease.