CNP-pGC-cGMP-PDE3-cAMP Signal Pathway Upregulated in Gastric Smooth Muscle of Diabetic Rats
作者： Ying-Lan Cai , Mo-Han Zhang , Xu Huang , Jing-Zhi Jiang , Li-Hua Piao
DOI: 10.1155/2015/305258
关键词:
摘要: Our previous studies have shown that CNP-NPR-B/pGC-cGMP is upregulated in the diabetic rats. The present study was designed to determine whether upregulation of signal pathway affects cGMP-PDE3-cAMP gastric smooth muscle. muscle motility observed by using isometric measurement. PDEs expressions tissue were immunohistochemistry, Western blotting, and RT-PCR methods. results demonstrated inhibitory effect CNP on spontaneous contraction antral circular potentiated STZ-induced rat. CNP-induced increase cGMP cAMP much higher than controls. expression PDE3 downregulated while levels gene PDE1, PDE2, PDE4, PDE5 not altered tissue. suggest sensitivity via activation CNP-pGC-cGMP-PDE3-cAMP rats, which may be associated with diabetes-induced disorder.
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Hui-Shu Guo, Comparative study in the effect of C-type natriuretic peptide on gastric motility in various animals World Journal of Gastroenterology. ,vol. 9, pp. 547- 552 ,(2003) , 10.3748/WJG.V9.I3.547
Jing-Bo Zhao, Jens Brøndum Frøkjær, Asbjørn Mohr Drewes, Niels Ejskjaer, Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus. World Journal of Gastroenterology. ,vol. 12, pp. 2846- 2857 ,(2006) , 10.3748/WJG.V12.I18.2846
J.Patrick Gray, George I. Drummond, David W.T. Luk, Joel G. Hardman, Earl W. Sutherland, Enzymes of cyclic nucleotide metabolism in invertebrate and vertebrate sperm Archives of Biochemistry and Biophysics. ,vol. 172, pp. 20- 30 ,(1976) , 10.1016/0003-9861(76)90043-6
C.David Nicholson, R.A.John Challiss, Mohammed Shahid, Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes Trends in Pharmacological Sciences. ,vol. 12, pp. 19- 27 ,(1991) , 10.1016/0165-6147(91)90484-A
A. F. Joslyn, M. S. Barnette, M. Grous, M. Fudge, W. J. Price, C. D. Manning, W. E. Thompson, F. C. Barone, H. S. Ormsbee III, Cyclic Nucleotides Increase During Neuronally Induced Relaxation of Sphincteric and Nonsphincteric Gastrointestinal Smooth Muscle Neurogastroenterology and Motility. ,vol. 2, pp. 65- 72 ,(2008) , 10.1111/J.1365-2982.1990.TB00010.X
Marilyn Grous, Alan F. Joslyn, Winston Thompson, Mary S. Barnette, Change in Intracellular Cyclic Nucleotide Content Accompanies Relaxation of the Isolated Canine Internal Anal Sphincter Neurogastroenterology and Motility. ,vol. 3, pp. 46- 52 ,(2008) , 10.1111/J.1365-2982.1991.TB00046.X
Ying-Lan Cai, Qian Sun, Xu Huang, Jing-Zhi Jiang, Mo-Han Zhang, Li-Hua Piao, Zheng Jin, Wen-Xie Xu, cGMP-PDE3-cAMP signal pathway involved in the inhibitory effect of CNP on gastric motility in rat Regulatory Peptides. ,vol. 180, pp. 43- 49 ,(2013) , 10.1016/J.REGPEP.2012.11.001
Dong-Yuan Xu, Lan Liu, Ying-Lan Cai, Xiang-Lan Li, Zhang-Xun Qiu, Zheng Jin, Wen-Xie Xu, Natriuretic peptide-dependent cGMP signal pathway potentiated the relaxation of gastric smooth muscle in streptozotocin-induced diabetic rats. Digestive Diseases and Sciences. ,vol. 55, pp. 589- 595 ,(2010) , 10.1007/S10620-009-0766-8
PATRICIA W. MAJOR, R. KILPATRICK, Cyclic AMP and hormone action. Journal of Endocrinology. ,vol. 52, pp. 593- 630 ,(1972) , 10.1677/JOE.0.0520593
Nicholas J. Talley, Lisa Young, Peter Bytzer, Johann Hammer, Melanie Leemon, Michael Jones, Michael Horowitz, Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life. The American Journal of Gastroenterology. ,vol. 96, pp. 71- 76 ,(2001) , 10.1111/J.1572-0241.2001.03350.X