cGMP-PDE3-cAMP signal pathway involved in the inhibitory effect of CNP on gastric motility in rat
作者： Ying-Lan Cai , Qian Sun , Xu Huang , Jing-Zhi Jiang , Mo-Han Zhang
DOI: 10.1016/J.REGPEP.2012.11.001
关键词:
摘要: In the present study, we investigated mechanism of C-type natriuretic peptide (CNP)-induced inhibitory effect on spontaneous contraction gastric antral smooth muscle to clarify CNP-NPR-B/pGC-cGMP downstream signal transduction pathway using organ bath and ELISA methods in rat. CNP significantly reduced amplitude increased contents cGMP cAMP tissue. presence IBMX, a non-selective phosphodiesterase (PDE) inhibitor, was suppressed; however, production but not still by CNP. EHNA, PDE2 did affect both CNP-induced inhibition increase generations tissue, while milrinone, PDE3 similar attenuated content cAMP. The results suggest that cGMP-PDE3-cAMP is also involved motility
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