Muscular and cardiorespiratory effects of pseudoephedrine in human athletes

摘要: Aims Pseudoephedrine (PSE) is a readily available over-the-counter nasal decongestant which structurally similar to amphetamine and included on the International Olympic Committee's list of banned substances. However date, little research has supported its putative ergogenic effect. This study investigated whether 180 mg dose PSE ingested 45 min prior exercise enhanced short-term maximal performance and/or altered related physiological variables. Methods A randomised, double-blind, crossover in 22 healthy male athletes. Results Maximum torque (mean ± s.d., n = 22) produced an isometric knee extension was 321.1 ± 62.0 Nm 295.7 ± 72.4 (placebo), peak power obtained ‘all-out’ 30 s cycle test 1262.5 ± 48.5 W 1228.4 ± 47.1 W (placebo) (P < 0.01, P < 0.03, respectively). Subjects were estimated be producing 96.9 ± 2.4% their possible leg force after ingestion, but only 95.3 ± 2.4% when not ingested. Bench press tasks total work during affected by ingestion PSE. Lung function following (P < 0.05) with FEV1 FVC significantly increased (P < 0.02, P < 0.01, respectively) although FEV1/FVC ratio altered. Heart rate elevated immediately sprint (P < 0.01) however, lactate concentration PSE. Conclusions The administration maximum torque, improvement performance, as well improving lung function.