Genotyping Non-small Cell Lung Cancer (NSCLC) in Latin America

摘要: Introduction Frequency of mutations in EGFR and KRAS non-small cell lung cancer (NSCLC) is different between ethnic groups; however, there no information Latin-American population. Methods A total 1150 biopsies NSCLC patients from Latin America (Argentina, Colombia, Peru, Mexico) were used extracting genomic DNA to perform direct sequencing gene (exons 18 21) 650 samples. In Mexico, Scorpions ARMS was also obtain a genetic profile. Results We report the frequency genes four countries ( n = 1150). 33.2% (95% confidence interval [CI] 30.5–35.9) (Argentina 19.3%, Colombia 24.8%, Mexico 31.2%, Peru 67%). The 16.6% CI 13.8–19.4). independently associated with adenocarcinoma histology, older age, nonsmokers, absence mutations. Overall response rate tyrosine kinase inhibitors EGFR-mutated 56) 62.5% 50–75) median overall survival 16.5 months 12.4–20.6). Conclusions Our findings suggest that lies Asian Caucasian populations therefore support heterogeneity around world.