KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib

作者: William Pao , Theresa Y Wang , Gregory J Riely , Vincent A Miller , Qiulu Pan

DOI: 10.1371/JOURNAL.PMED.0020017

关键词: Adenocarcinoma of the lungOncologyEpidermal growth factor receptorKRAS Mutation AnalysisErlotinibCancer researchGefitinibKRASInternal medicineMutationErlotinib HydrochlorideMedicine

摘要: Background Somatic mutations in the gene for the epidermal growth factor receptor (EGFR) are found in adenocarcinomas of the lung and are associated with sensitivity to the kinase …

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