Mutations and addiction to EGFR: the Achilles ‘heal’ of lung cancers?
作者： Adi F. Gazdar , Hisayuki Shigematsu , Joachim Herz , John D. Minna
DOI: 10.1016/J.MOLMED.2004.08.008
关键词:
摘要: The epidermal growth factor receptor (EGFR) gene product is a tyrosine kinase (TK) that affects many important downstream pathways. recent finding mutations in EGFR predict the response of lung cancers to therapies target TK domain has generated considerable interest. are associated with adenocarcinoma histology, oriental origin, female gender and never-smoker status. Most structures appear be essential for phosphorylation function gene. Cancer cells mutant genes might become physiologically dependent on continued activity maintenance their malignant phenotype; however, this also therapy.
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