Risk factors for myocardial injury and death in patients with COVID-19: insights from a cohort study with chest computed tomography.

摘要: AIMS Whether pulmonary artery (PA) dimension and coronary calcium (CAC) score, as assessed by chest computed tomography (CT), are associated with myocardial injury in patients coronavirus disease 2019 (COVID-19) is not known. The aim of this study was to explore the risk factors for death investigate whether has an independent association all-cause mortality COVID-19. METHODS AND RESULTS This a single-centre cohort including consecutive laboratory-confirmed COVID-19 undergoing CT on admission. Myocardial defined high-sensitivity troponin I >20 ng/L A total 332 median follow-up 12 days were included. There 68 (20.5%) deaths; 123 (37%) had injury. PA diameter higher compared without [29.0 (25th-75th percentile, 27-32) mm vs. 27.7 (25-30) mm, P < 0.001). independently increased [adjusted odds ratio 1.10, 95% confidence interval (CI) 1.02-1.19, = 0.01] hazard (HR) 1.09, CI 1.02-1.17, 0.01]. Compared injury, lower prevalence CAC score zero (25% 55%, 0.001); however, did emerge predictor multivariable logistic regression. Cox regression (adjusted HR 2.25, 1.27-3.96, 0.005). Older age, estimated glomerular filtration rate, PaO2/FiO2 admission other predictors both death. CONCLUSIONS An diameter, CT, factor approximately two-fold