Antioxidant potential and antimicrobial screening of some novel imidazole derivatives: greenway efficient one pot synthesis
作者： Jayaraman Jayabharathi , Venugopal Thanikachalam , Nagarajan Rajendraprasath , Kanagarathinam Saravanan , Marimuthu Venkatesh Perumal
DOI: 10.1007/S00044-011-9702-5
关键词:
摘要: A series of substituted imidazoles have been synthesized under solvent-free condition by grinding 1,2-diketone, aromatic aldehyde, and ammonium acetate in the presence molecular iodine as catalyst. The short reaction time easy workup make this protocol practically economically attractive are characterized NMR spectra, X-ray, mass, CHN analysis. Their antioxidant potential were evaluated using different vitro models namely, DPPH (1,1-diphenyl-2-picrylhydrazyl) radical, superoxide anion, hydroxyl radical scavenging activities. antibacterial screening against Staphylococcus aureus, Escherichia coli, Klbesiella pneumoniae antifungal activity Aspergillus niger, flavus, Candida-6 also evaluated. Among all, dimethoxyphenyl substituent at N3 imidazole derivatives exhibited highest hydroxy anion activities, whereas fluorophenyl C2 activity.
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