Increased translocation of bacteria from the gastrointestinal tracts of tumor-bearing mice.

摘要: Aerobic gram-negative bacilli and other indigenous gastrointestinal (GI) bacteria are important opportunistic pathogens in immunosuppressed cancer patients. These same frequently translocate from the GI tracts of mice by single injections certain anticancer drugs or T-lymphocyte impairments. Since similar cellular humoral immune deficiencies may be present tumor-bearing host, we sought to determine if progressive growth a tumor alone would sufficient enhance translocation murine tract. Pathogen-free DBA/2 were injected intraperitoneally with 10(6) viable sarcoma 180 (S-180) cells 0.5 ml sterile buffer. Mesenteric lymph nodes, livers, spleens, kidneys tested for presence translocated aerobic on various days after injection. Immunity was assessed measuring footpad delayed-type hypersensitivity serum hemagglutinins sheep erythrocytes. Overall, infected 33 92 S-180-bearing (36%) only 9 99 control (9%) (P less than 10(-6)). Cumulatively, 50 460 sites (10.9%) as opposed 485 (1.9%) animals 10(-7)). often infect more one site mice, but not controls. 11 times once controls, even though mean cecal population levels these relatively low (range, 4.33 5.28 log10 per g). The S-180 throughout period observation. had significantly suppressed 0.04) hemagglutinin responses when sensitized 4 8 associated neutrophilic leukocytosis slight drop platelet counts; no bleeding detected. Thus, tract mesenteric nodes organs increased this increase caused bacterial overgrowth intestines neutropenia.