Cadherin Switching and Bladder Cancer
作者： Richard T. Bryan , Chris Tselepis
DOI: 10.1016/J.JURO.2010.04.016
关键词:
摘要: Purpose: Progression to or presentation with muscle invasive disease represents the critical clinical step in bladder cancer, necessitating more aggressive therapy and carrying a significantly worse survival rate. Bladder tumors typically show decreased expression of cell-cell adhesion molecule E-cadherin as grade stage progress, accompanied by increased N-cadherin P-cadherin tumors. This phenomenon has been described cadherin switching may represent key invasion. We introduce some concepts mediated cell biology, describe detail for cancer.Materials Methods: performed PubMed® search articles summarizing important biology presenting primary evidence cancer.Results: Cadherin promotes malignant phenotype cancer patients laboratory based experimental systems. Bladd...
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