Serotonin 1A receptor acts during development to establish normal anxiety-like behaviour in the adult

摘要: Serotonin is implicated in mood regulation, and drugs acting via the serotonergic system are effective treating anxiety depression. Specifically, agonists of serotonin1A receptor have anxiolytic properties, knockout mice lacking this show increased anxiety-like behaviour. Here we use a tissue-specific, conditional rescue strategy to that expression primarily hippocampus cortex, but not raphe nuclei, sufficient behavioural phenotype mice. Furthermore, using nature these transgenic mice, suggest during early postnatal period, adult, necessary for rescue. These findings developmental processes help establish adult In addition, normal role development may be different from its function when activated by therapeutic intervention adulthood.