O→S Relay Deprotection: A General Approach to Controllable Donors of Reactive Sulfur Species.
作者： Jianming Kang , Shi Xu , Miles N. Radford , Wenjia Zhang , Shane S. Kelly
关键词:
摘要: Reactive sulfur species (RSS) are biologically important molecules. Among them, H2 S, hydrogen polysulfides (H2 Sn, n>1), persulfides (RSSH), and HSNO believed to play regulatory roles in sulfur-related redox biology. However, these molecules unstable difficult handle. Having access their reliable controllable precursors (or donors) is the prerequisite for study of species. Reported this work preparation evaluation a series O-silyl-mercaptan-based sulfur-containing which undergo pH- or F- -mediated desilylation release corresponding Sn , RSSH, controlled fashion. This O→S relay deprotection serves as general strategy design -triggered RSS donors. Moreover, we have demonstrated that O-silyl groups donors could be changed into other protecting like esters. should allow development with activation mechanisms (such esterase-activated donors).
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