Exon 8 amplification of epidermal growth factor receptor (EGFR) in invasive breast carcinomas.
作者： Efthimia Souka , Evaggelos Alexiadis , Irini Theohari , Ioanna Giannopoulou , Christos Papadimitriou
DOI: 10.1111/J.1365-2559.2012.04315.X
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摘要: Souka E, Alexiadis Theohari I, Giannopoulou Papadimitriou C & Nakopoulou L (2012) Histopathology 61, 644–651 Exon 8 amplification of epidermal growth factor receptor (EGFR) in invasive breast carcinomas Aims: The rate EGFR cancer ranges between 0% and 15%. Recent studies have focused on the status cytosine–adenine (CA) repeats intron 1 gene correlated it with increased protein. aim this study was to investigate, for first time, significance coding exon cancer. Methods results: We investigated, by means real-time polymerase chain reaction (PCR), 148 paraffin-embedded tissue sections, 115 carcinoma 33 controls. Immunohistochemistry utilized detect human 2 (HER2) expression. Univariate multivariate statistical analyses were performed evaluation our results. observed 7.8% patients, immunodetected 9.6%. positively expression (P < 0.0001), HER2 (P = 0.023), coexpression EGFR/HER2 (P < 0.0001) nuclear grade (P = 0.047), inversely ER protein (P = 0.047). Conclusions: It appears that sequence exhibits similar biological behaviour regulatory 1, leading elevated levels
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